An update on new oral PDE5 inhibitors for the treatment of erectile dysfunction

While the phosphodiesterase 5 (PDE5) inhibitors sildenafil, vardenafil and tadalafil have transformed the treatment of men with erectile dysfunction, a number of new PDE5 inhibitors have become available in the Far East. In this Review, the authors describe the efficacy of these new drugs, and briefly review the current state of development of other pharmacological therapies for erectile dysfunction, such as gene therapy and stem cell therapy.