Abstract 20023: Impact of Targeted Temperature During Therapeutic Hypothermia: A Pooling Analysis of Published Literature

Introduction: Two small RCTs demonstrated benefit of therapeutic hypothermia (TH) after out-hospital cardiac arrest (OHCA). We explored the benefit of targeted temperature during TH and also performed an updated meta-analysis to determine the intervention effect in the community. Methods: We identified studies by searching electronic databases (MEDLINE, EMBASE and Cochrane Library). We selected RCTs and cohort studies restricted to those reporting achieved temperature during TH after OHCA, and describing mortality and neurological outcomes at discharge. Studies were assessed for risk of bias. Data from all individual hypothermia arms were pooled by achieved temperature. Pooled outcomes were compared across achieved temperatures. Meanwhile, we meta-analyzed controlled studies comparing hypothermia against normothermia. Results: The search identified 32,275 studies of which 24 studies (34 hypothermia arms) were used in the pooling analysis and 14 controlled studies were meta-analyzed. Pooling analysis repor...