Anti-inflammatory effect of procalcitonin on in vitro LPS-stimulated human PBMC

Sepsis is a leading cause of death in critically ill patients and is characterized by a marked increase of the host proinflammatory cytokine release that is precipitated by infectious agents. The sepsis response to therapy has not appreciably improved. The procalcitonin (PCT) concentration is increased in the serum samples of septic patients and correlates with severity of the illness. LPS is a pivotal bacterial product involved in pathogenesis of sepsis and septic shock. Preventing the beginning of inflammatory systemic cascade by means of LPS modulating agents might have a valuable effect in the control of such deadly illness. The aim of the present study was to evaluate the potential effect of procalcitonin on in vitro LPS-induced release of cytokines from human PBMC.