Abstract 16041: Beneficial Effects of Chronic Statin Pretreatment on Long-Term Prognosis in Patients With Acute Myocardial Infarction

Introduction: Chronic administration of statins before onset of acute myocardial infarction (AMI) has protective effects on coronary microcirculation and reduces the infarct size irrespective of presence of dyslipidemia. It is not well elucidated whether the beneficial effects of statin pretreatment would be persistent on the chronic stage of infarction. Hypothesis: The protective effect of pretreatment of statin could be associated with the improvement of long-term prognosis after AMI. Methods: Among consecutive 803 patients with AMI who admitted between April 2004 and September 2012, we followed up 746 patients (age: 64±13 years, male: 82.4%) whose clinical history including medication before administration was confirmed. The primary endpoint was all-cause death. Results: Statins were administered in 112 patients (15.0%) before hospital administration for AMI. Patients with pretreatment of statins had significantly lower peak CK (2248±2008 vs. 3400±3663 IU/L, p=0.001) and CK-MB (153±126 vs. 245±390 IU/L...