High-Dose Vitamin D Supplementation During Pregnancy and Asthma in Offspring at the Age of 6 Years

N Brustad, AU Eliasen, J Stokholm, K Bonnelykke, H Bisgaard, BL Chawes. JAMA. 2019;321(10):1003–1005 To determine if high-dose vitamin D supplementation given during pregnancy reduced the risk of the development of asthma and related disorders in offspring by age 6 years. This study included 545 children (of the 581 children included in the original study) whose mothers had been randomly assigned to receive high-dose vitamin D or placebo during pregnancy. The initial study was performed in 2009 to 2010, in which 623 women were enrolled. These women were randomly assigned to receive an additional 2400 IU per day of vitamin …