Effect of transfusion, leukocyte-depleted blood product on onset of new septic shock and mortality in septic shock

A number of studies have observed decreased survival associated with transfusion. Leukocyte-mediated immunosuppression may contribute to postoperative infectious complications. There is evidence for a benefit with the use of leukocyte reduced transfusion, but it is unclear among septic shock patients. In Japan, leukocyte-depleted blood products have been used since 2007. We assessed the effect of transfusion and the efficacy of the use of leukocyte-depleted blood products for new onset of septic shock and mortality among patients with septic shock.