Predictive value of ankle brachial index combined with serum highsensitivity C-reactive protein for extent of coronary artery disease

Objective:To investigate whether the combination of ankle brachial index(ABI) and serum high sensitivity C-reactive protein(hs-CRP) could improve their diagnosis value for extent of coronary artery disease(CAD) in patients. Method:The study population consisted of 120 patients scheduled to undergo elective cardiac catheterization for suspected CAD(from september 2010 to December).Collected data included ABI and hs-CRP before underwent coronary angiography.According to the degree of coronary stenosis(estimated by Gensini score) and the number of coronary artery stenosis,all subjects were divided into different groups. Result:With ABI 0.9 and hs-CRP 3 mg/L as the cutoff value,combined the 2 methods to predict serious stenosis and multi-vessel CAD,the sensitivity was respectively 85%,92%,and the specificity was respectively 69%,61%.Compared with using ABI or hs-CRP alone,the sensitivity of the 2 joint detection for predicting CAD increased significantly(P0.05);the specificity decreased,but the difference was not statistically significant. Conclusion:ABI and hs-CRP are closely related to the extent of coronary artery disease,and the combination of ABI and hs-CRP may have higher practical value for predicting the extent of coronary artery disease.