Toll-like Receptor 3 Deficiency in a Child with Recurrent Infections and Diabetes Mellitus

There are more than 400 different primary immune deficiencies worldwide. Among them, patients with humoral immunodeficiency are more common among adaptive immune defects. Most of the innate immune defects affect the phagocytic system. There are a few cases of toll-like receptor deficiency with innate immune defects like TLR3 mutations which usually present with Herpes simplex encephalitis. Herein we report a two years old boy with TLR3 deficiency who presented with recurrent infections and type one diabetes mellitus.