Oxidative Stress in Hepatitis C Virus - Human Immunodeficiency Virus co-infected patients

ABSTRACT Introduction and objectives: Human immunodeficiency virus (HIV) and Hepatitis C Virus (HCV) co-infection generates sustained inflammation with increased reactive oxygen species production. Pathogenic impact of systemic oxidative stress is recognized to influence on drug treatment and follow up. The aim of this case control study was to compare the redox status in HCV-HIV co-infected respect to HIV infected individuals and to explore relation between redox and HIV follow-up variables. Patients or Materials and methods: Blood samples were drawn from 330 individuals divided into three groups: HIV, HCV-HIV and presumable healthy subjects. Redox, hematological, hemochemical, immunologic and virological indexes were determined. Results: Both HIV groups had significant differences in global indexes of damage and antioxidant status (p Conclusions: These results corroborate that oxidative stress occurs in HIV condition and also during HCV-HIV co-infection, with different molecular changes of follow-up indexes. Redox indexes diagnosis should be considered in early diagnosis and treatment of HCV-HIV co-infection.