Serological Biomarkers of Dermatomyositis – Associated Interstitial Lung Disease
2016
Dermatomyositis (DM) is a subset of idiopathic inflammatory myopathies (IIM) which is characterized by chronic
inflammation of skin and muscle weakness, and often involving other organs, such as skin, heart, gastrointestinal
tract, pulmonary, and joints. Interstitial lung disease (ILD) is the most common internal organ manifestation that affects
the prognosis of DM patients. The mortality is very high in DM-ILD patients especially in those with rapid ILD due to
the lack of effective treatment. An early diagnosis of ILD in DM patients is critical important. In recent years, many
studies focused on detecting serological biomarkers that can be used in prediction and evaluation of DM-ILD. Here we
reviewed recent studies about serological biomarkers of DM-ILD. An overview of those biomarkers may help us have a
better management of DM-ILD and may give us a better understanding about the pathogenesis of DM-ILD.
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