Correlation of renal hemodynamics and vascular endothelial function in patients with hypertensive disorders in pregnancy

Objective To explore the correlation between renal hemodynamics and vascular endothelialfunction in patients with hypertensive disorders in pregnancy(HDP) through color Doppler ultrasonography. Methods 80 cases of HDP patients were divided into gestational hypertension group(26 cases), gently preeclampsia group(28 cases)and severe preeclampsia group(26 cases) according to their condition and 30 cases of normal pregnancy women were chosen as the control group. The resistive index(RI), pulsatility index(PI), peak systolic velocity(PSV), the end diastolic velocity(EDV) and S/D of renal interlobar artery were tested by Color Doppler ultrasonography. Meanwhile,the 1evels of serum endothelin-1(ET-l) and nitric oxide(NO) were examined. Results(1) The One-way ANOVA of ET-1 and NO were significantly different(P0.01). The level of serum ET-1 in patients with HDP were significantly higher than that in the control group(P0.01) and serum NO in patients with HDP were lower than that in the control group(P0.01). The level of serum ET-1 increased and level of serum NO reduced along with the exacerbation.(2)The One-way ANOVA of RI, PI, EDV and S/D were significantly different(P0.05). The levels of RI, PI, S/D in preeclampsia patients were significantly higher than that in the control group(P0.05). The Level of EDV in preeclampsia patients were significantly lower than that in the control group(P0.05).(3) The RI, PI and S/D of renal interlobar artery was significantly positively related to the level of serum ET-1(P0.01) and was negatively related to the level of serum NO(P0.01). Conclusions The renal hemodynamics evaluated by color Doppler ultrasonography correlated to serum ET-1 and NO in endothelial function and could reflect the changes of renal hemodynamics and renal damage in HDP patients.