Abstract W P65: Clevidipine Outperforms Other Agents in Emergent Acute Hypertension Treatment in Ischemic Stroke Pre-rt-PA

Hypothesis: Minimizing Acute Hypertension Treatment (AHT) time in rt-PA candidates is one means to reduce door to needle times. We have used nicardipine, labetalol and clevidipine at our institution for treatment of ischemic stroke patients in the ED. We assessed the hypothesis that if one agent could be identified that safely outperformed others, door to blood pressure control times could be improved in patients otherwise eligible for rt-PA. Methods: We evaluated all ischemic stroke ED patients receiving rt-PA at our institution from 1/1/07 - 1/31/14; data from ischemic stroke patients requiring AHT prior to administration of rt-PA were analyzed by agent. Results: Two hundred thirty two patients received rt-PA; 32 (14%) required AHT. Diagnoses: Unspecified Cerebral Occlusion, 21 (9%); Embolic Ischemic Stroke, 8 (3%); Thrombotic Ischemic Stroke, 1 (<1%); Vertebral Artery Occlusion Ischemic Stroke, 1 (<1%); Carotid Artery Occlusion Ischemic Stroke, 1 (<1%). Data were analyzed by agent. Five patients were e...