Pharmacokinetic and pharmacodynamic alterations in the Roux-en-Y gastric bypass recipients

Objective:We conducted a pharmacokinetic (PK) study and a pharmacodynamic (PD) study to assess whether Roux-en-Y gastric bypass (RYGB) surgery is associated with significant changes to PK and PD of oral medications.Background:The effect of RYGB on oral drug disposition is not well understood.Methods