SP0168 The use of xo inhibitors in ckd – pros and cons

The association of chronic kidney disease (CKD) and hyperuricaemia is well established, and many observational studies have reported that hyperuricaemia is associated with development and progression of CKD. Potential mechanisms of this observation will be discussed, including the potential for urate as an ‘innocent bystander’ or as a causal mediator contributing directly to kidney injury. Xanthine oxidase inhibitors (XOIs) are the most widely used urate-lowering drugs. Current evidence for efficacy and safety of XOIs for preventing or delaying progression of chronic kidney disease will be presented, both in the general population and in people with gout. The challenges of XOI use in people with CKD will also be discussed, with specific reference to allopurinol dosing in CKD, and cardiovascular safety of febuxostat. Disclosure of Interest N. Dalbeth Consultant for: Kowa, Horizon