Heart dose associated with overall survival in locally advanced NSCLC patients treated with hypofractionated chemoradiotherapy

Abstract Association of heart dose and overall survival was investigated in a cohort including 469 locally-advanced NSCLC patients receiving daily low-dose hypofractionated chemo-radiotherapy. Significant associations were found over a range of dose parameters. Multivariate analysis showed significant associations of heart_V 2Gy :HR = 1.007% −1 (95% CI:1.002–1.013; p  = 0.006), age:HR = 1.026 year −1 (1.011–1.042; p  = 0.001) and GTV volume:HR = 1.001 cc −1 (1.000–1.002; p  = 0.006) with overall survival.