Local Synthesis of IgG Subclasses in Patients With Alzheimer's -Disease

Summary Immunological studies have shown abnormalities of the humoral iminune response in several Alzheimer's disease patients such as the increase of seric IgG, Eleven Alzheimer's disease patients were studied. Serum and cerebrospinal fluid were obtained simultaneously. Album and IgG subclasses were measured in both biological fluids by simple radial immunodiffusion. IgG subclasses intrathecal synthesis was were calculated by the improved hyperbolic function and CSFI serum quotlent dlagram of Reiber. Local IgG subclass synthesis in a varied number of patients were produced. IgG, was synthesized in 6 patients and IgG, in 4 patients. Seven patients showed local synthesized IgG, and 10 patients made IgG, in central nervous system . No significant alterations were found in the age- related blood brain barrier function. These results support the hypothesis about that an irnrnune- dysreplation and I or autoimmunity mechanism may play an important role in the pathogenesis of the Alzheimer's disease.