SUN-PP126: Effect of a Preventive Diet Supplementation with Omega-3 Polyunsaturated Fatty Acids on Tumor Growth in Nude Mice: Pilot Study

study aimed to examine nutritional outcomes in patients (pts) presenting for minimally invasive oesophagectomy (MIO). Methods: Pts were enrolled in an ERAS protocol including written education, pre-emptive analgesia, early mobilisation & enteral nutrition (EN) via a jejunostomy tube (commenced post-op day 1). Oral diet was introduced early and all pts were discharged on overnight EN for 1 month. Body composition assessment, by computed tomography (CT) and multi-frequency bioelectrical impedance analysis (BIA), progression to oral diet and pt-reported global quality of life (QOL) scores (EORTC QLQ-C30) were prospectively collected pre-op and at 1, 3 and 6 months post-op. Results: A total of 54 pts (74% males) participated. The mean age, pre-op weight loss and BMI were 62 years, 4.7% and 28.6 kg/m2 respectively. Only 15% had a healthy BMI, 54% were overweight and 29% obese. CT analysis found 47% to be sarcopenic pre-op. Oral diet was introduced after a mean of 4.7 days and EN was reduced to overnight. The mean length of stay was 11 days. Sarcopenic pts spent on average 5.2 days longer in hospital than non-sarcopenic (14 days Vs 8.8 days p=ns). Weight decreased from 83 kg pre-op to 79.9 kg at 1 month (p = 0.0001) and 74.2 kg by 6 months. BIA found lean tissue mass (LTM) decreased from 48.2 kg to 42.2 kg (p = 0.016). Global QOL decreased at 1 month but returned to pre-op values by 3 months post-op. Conclusion: An ERAS protocol is associated with early discharge and assists in post op recovery. There is a significant decline in nutritional status, particularly LTM, however this stabilises at 3 months at which time QOL scores return to baseline.