REJECTION RESPONSES TO ALLOGENEIC HEPATOCYTES BY RECONSTITUTED SCID MICE, CD4 KO, AND CD8 KO MICE1,2

Introduction.The purpose of the current study was to investigate the capacity of CD4+, CD8+, or non-T cells to independently initiate acute rejection of allogeneic hepatocytes using reconstituted SCID, CD4 or CD8 knockout (KO) recipient mice.Methods.Allogeneic hepatocytes (FVB/N, H-2q) were transpla