FRI0219 CD4+CD25+FOXP3+ REGULATORY T CELLS IN SYSTEMIC LUPUS ERYTHEMATOSUS PATIENTS: THE NEGATIVE ASSOCIATION WITH DISEASE ACTIVITY, ACUTE COURSE, TRANSITIONAL B CELLS AND IGG LEVELS

Background CD4+ CD25+ Foxp3+ regulatory T (Treg) cells play a key role in maintaining peripheral tolerance and preventing autoimmune disease. Quantitative and/or qualitative deficiencies of Treg have been associated with immune disturbances in systemic lupus erythematosus (SLE). Objectives The main goal of the study was to determine the relationship of CD4+CD25+FoxP3+Treg cells with clinical and immunological manifestations in SLE patients (pts). Methods Frequencies and absolute numbers of peripheral blood CD4+CD25+FoxP3+Treg cells were assessed in 21 healthy donors and 20 SLE pts (2012 SLICC classification criteria); (1M/19F); age 32±13 years; disease duration median (25–75 percentile) 5(1-10) years; SLEDAI2K≥10 - 15(10-22) (14 pts), Results Compared with healthy donors, SLE pts demonstrated significant lower the absolute number of Tregs (0.05; 0.04-0.06 vs 0.03;0.02-0.05x109/L, p Conclusion Decreased amount of T regs in SLE is associated with high disease activity, acute course and expansion of autoreactive B cells. References [1] Zhang SX, Ma XW, Li YF, Lai NL, Huang ZH, Fan K, Wang CH, Li XF. The Proportion of Regulatory T Cells in Patients with Systemic Lupus Erythematosus: A Meta-Analysis. J Immunol Res. 2018 Sep 3;2018:7103219. doi: 10.1155/2018/7103219. [2] Żabinska M, Krajewska M, Kościelska-Kasprzak K, Jakuszko K, Bartoszek D, Myszka M, Klinger M. CD4(+)CD25(+)CD127(-) and CD4(+)CD25(+)Foxp3(+) Regulatory T Cell Subsets in Mediating Autoimmune Reactivity in Systemic Lupus Erythematosus Patients. Arch Immunol Ther Exp (Warsz). 2016 Oct;64(5):399-407. doi: 10.1007/s00005-016-0399-5. Disclosure of Interests None declared