CouldTorasemidebeaprophylacticagentof contrastinducedacutekidneyinjury? Areviewaboutthisfield

2013 
Contrast Induced Acute Kidney Injury (CI-AKI), due to the use of contrast media in radiographic procedures, is the leading cause of acute renal failure in hospitalized patients, and is associated with prolonged in-hospital stay and increased morbidity, mortality, and costs. Howev - er only peri-procedural hydration is now used universally as its preventive strategy. Some stud - ies indicates that renin-angiotensin-aldosterone system (RAAS) is possibly responsible for the de - velopment of contrast-induced nephrotoxicity through mediating abnormalities of renal perfu - sion and other mechanisms. And torasemide, known as loop diuretics, could inhibit RAAS through its anti-aldosteronergic function. There - fore, speculation about torasemide's prevention of CI-AKI could be firmly made. Intravenously ad - ministrated torasemide would be promising as a future prophylactic agent, possibly in combina - tion with other strategies such as adequate peri- procedural hydration and other renal protective agents, in the prevention of CI-AKI. In this context, we review the background and the role of RAAS on the development of CI-AKI, and discuss the pharmacologic individuality of torasemide on RAAS and torasemide's preven - tive effect on CI-AKI.
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