Diffuse hyperkeratotic lesions in a 4-year-old HIV-infected girl

A 4-year-old girl arrived in Italy from Cameroon 8 months previously. She developed severe pneumonia several weeks later and was hospitalised. As part of her care, she underwent an immune workup and a severe depletion of CD4+ T cells (7 cell/mm3) was revealed with HIV copy number of 1.8 million/mm3. She was given lamivudine and lopinavir/ritonavir. After about 6 months of therapy, blood tests showed increased CD4+ T …