P531: An observational multicenter study in Turkey to evaluate beta-hydroxy-beta methyl butyrate, L-arginine and L-glutamine usage patterns in daily practice: sarcopenia in elderly

Results: There were 300 patients aged over 65, the mean age was 76.48±7 years [65–94 years]. 49% of patients were aged 75 years and older. Our series included 162 men (54%) and 138 women (46%), polypathological patients (17%), polymedicated patients (25%). As past medical history, there was: heart disease (47.5%), diabetes (21.3%), neoplasia (8.7%), gastric ulcers (7.8%), stroke (7.8%) and hepathopathy (0.4%). In biology, we noted: anemia (50.7%), hypoalbuminemia (55.7%). The mean dose of Sintrom used was 2.6±0.9G/d. The mean duration of AVKs treatment was 7.6 months. AVK overdose was noted in 34% of cases (7% showed hemorrhagic complication). The Warfarin INR was within the therapeutic range in 56%. Contributing factors were: combination therapy (6 cases), bad observance (3 cases), infectious syndrome (1 case), and disorders of blood crass (2 cases). In 85% of cases the overdose had occurred at the waning of the first three months of treatment. Conclusion: The frequency of thromboembolic diseases and their severity and the benefit of anticoagulation, requires an individual and periodic evaluation of the risk/benefit ratio.