Translational Research in Psoriasis.

Translational research is a coordinated process that converts scientific knowledge about diseases from basic research into the development of therapeutic or diagnostic procedures in order to improve public health. Recent insights into the pathogenesis of psoriasis have greatly promoted the rational development of new therapeutic approaches. The integration of genetic predisposition and pathogenetic events defined the cytokine cascade as a target for therapeutic interventions. Applying various phases of translational research has enabled development of novel therapies that combine high efficacy with convincing safety profiles, with important implications for public health.