Abstract WMP78: Follow-up High-Sensitivity C-reactive Protein is Associated With Early Recurrent Ischemic lesions in Acute Ischemic Stroke

Background: Early recurrent ischemic lesions (ERILs) on diffusion-weighted imaging (DWI) after acute ischemic stroke have been considered as a potential marker of early recurrent symptomatic stroke. The aim of this study to explore the impact of High-sensitivity C-reactive protein (hsCRP) levels at different time points on ERILs. Method: We prospectively enrolled 484 patients with acute ischemic stroke who underwent DWI and whose plasma and serum biomarkers (hsCRP, D-dimer, and brain natriuretic protein [BNP]) within 24 hours of onset and subsequently at 7 days after onset. Baseline characteristics, stroke features, initial National Institutes of Health Stroke Scale (NIHSS) score, and DWI lesion volume were recorded. ERILs were defined as new ischemic lesions on 7-day DWI, which were outside the vascular territory of index stroke with arterial occlusion and the same or outside the vascular territory of index stroke with arterial stenosis. Results: ERILs were observed in 146 patients (30.2%). In univariate analysis, atrial fibrillation (p=0.040), higher initial NIHSS score (p Conclusions: Underlying inflammation after acute ischemic stroke may be associated with ERILs.