[The preparation of PELGE-NP and a study of the factors affecting their diameter].

Objective To prepare Poly(ethylene glycol) - poly (lacticacid-co-glycolicacid)- poly(ethylene- glycol) nanoparticles (PELGE-NP) and investigate the factors affecting their diameter. Methods PELGE were synthesized by ring-opening polymerization, PELGE nanoparticles(PELGE-NP) were prepared by using the emulsion-solvent evaporation technique (O/W). Orthogonal design was applied to optimize the preparation technology on the basis of the single factor evaluation. Results The optimal conditions for preparing nanoparticles included the PELGE at concentration of 10 mg/ml, the ratio of acetone/DCM at 2/3, the F68 at concentration of 3%, and the volume ratio of O/W at 1/8(V/V). Conclusion The prepared PELGE nanoparticles are spherical and discrete particles without aggregation; they are smooth in surface morphology, and their diameters range from 60 nm to 100 nm.