Changes of Vα24~+Vβ11~+,CD161~+Vα24~+NKT Cells in Peripheral Blood of Systemic Lupus Erythematosus Patient

Objective To explore the changes of the amount and function of Vα24+Vβ11+,CD161+Vα24+NKT cells in the peripheral blood of systemic lupus erythematosus(SLE)patients. Methods The amount of Vα24+Vβ11+,CD161+Vα24+NKT cells in the peripheral blood of 30 SLE cases and 30 healthy persons were detected by flow cytometry. Results Vα24+Vβ11+,CD161+Vα24+NKT cells in the peripheral blood of SLE patients were significantly lower than that of normal control(P 0.05). Vα24+Vβ11+ and CD161+Vα24+NKT cells in the peripheral blood of SLE patients positively correlated with the level of the complement(C3,C4)and negatively correlated with SLE disease activity index (SLEDIA)and ESR. Conclusion Activated NKT cells decreased in the peripheral blood of SLE patients. Vα24+Vβ11+ and CD161+Vα24+NKT cells might be involved in the pathogenesis and development of SLE.