Plasmacytoid dendritic cell driven induction of Tregs is strain-specific and correlates with spontaneous acceptance of kidney allografts

Nicholas A. Oh,Thomas O’Shea,Dorothy Ndishabandi,Qing Yuan,Shuahuan Hong,Jared Gans,Jifu Ge,Sean F Gibney,Catharine M. Chase,Chao Yang,Ivy A. Rosales,K. Shinoda,Benjamin A. Drew,Lisa Kojima,Paul S. Russell,Joren C. Madsen,Robert B. Colvin,Alessandro Alessandrini

Plasmacytoid dendritic cell driven induction of Tregs is strain-specific and correlates with spontaneous acceptance of kidney allografts

2019

Nicholas A. Oh
Thomas O’Shea
Dorothy Ndishabandi
Qing Yuan
Shuahuan Hong
Jared Gans
Jifu Ge
Sean F Gibney
Catharine M. Chase
Chao Yang
Ivy A. Rosales
K. Shinoda
Benjamin A. Drew
Lisa Kojima
Paul S. Russell
Joren C. Madsen
Robert B. Colvin
Alessandro Alessandrini

Background:DBA/2J kidney allografts, but not heart allografts, are spontaneously accepted indefinitely in C57BL/6 (B6) mice, through regulatory tolerance mechanism dependent on Foxp3+ cells. In contrast, B6 kidneys are rejected within a week in DBA/2J recipients. We hypothesized that the tolerogenic

Keywords:

Immunology
Plasmacytoid dendritic cell
Diabetes mellitus
Strain (chemistry)
Medicine
Kidney
T cell
Adoptive cell transfer
Heart transplantation
MHC class II
Major histocompatibility complex
Bone marrow
FOXP3

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