Abstract W P31: Are Current Lipid Profile Measurements Reliable for Monitoring Carotid Plaque??

Objective: To test the hypothesis that lipid indices have a role in monitoring lipid-rich necrotic core (LRNC) burden and to see if this varies with statin exposure. METHODS: Cohort of 73 symptomatic carotid stenosis patients were identified with MR angiogram imaging to assess their carotid LRNC percentage determined by 2 independent radiologists and corresponding lipid profiles . Patients were further stratified into two groups as statin naive ( 1 month exposure to statin).Simple linear regression was performed between with the dependent variable of LRNC size and independent variables of LDL: HDL ratio, TG :HDL ratio and HDL alone. RESULTS: Of 73 patients with LRNC percentage reported 26 were statin naive and 47 were term statin users. Overall LDL:HDL, TG:HDL-C and HDL-C were associated (r,P){moderately(0.37, 0.049)}, {weakly(0.23,0.049)}, {Moderately (-0.30 ,0.01)} LRNC size respectively. Patients with statin naive status, LDL:HDL, TG:HDL-C and HDL-C ...