[Role of Epstein-Barr virus in the pathogenesis of lymphogranulomatosis. Immunohistochemical and molecular-biological (hybridization in situ) research].

: EBV was found in 72.7% of 66 LGM patients aged from 4 to 76 years. EBV occurred in 100% of lymphoid depletion, 81% of mixed-cell variant and in 66.6% of nodular sclerosis. The occurrence of virus-positive cases was significantly higher at the age of under 10 years and over 50 years (100%). In the intermediate group it was 65.4 (p < 0.01). Necrotic changes in the lymph nodes were observed more frequently (p < 0.05) when EBV was present. The virus-positive cases of mixed-cell LGM are characterized by increased number of tumor and plasma cells (p < 0.05). EBV was also in a latent state without signs of lytic replication. The influence of the virus manifested in higher expression of antigens CD30 (p < 0.05) and bcl oncoproteins (p < 0.01) as well as in weak CD79 expression (p < 0.05).